Description

2-tert-Butyl-4-Fluoro-5-Nitro-1H-Indole is a high-purity, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is valued for its unique molecular architecture, which combines a sterically hindered tert-butyl group with electron-withdrawing nitro and fluoro substituents on the indole scaffold. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a core scaffold for developing new herbicides, fungicides, and insecticides with enhanced activity and selectivity.
• Material Science: Used in the research and development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis, including cross-coupling and C-H functionalization reactions.

Basic Information

Product Name	2-tert-Butyl-4-Fluoro-5-Nitro-1H-Indole
CAS No.	952664-90-3
Molecular Formula	C₁₂H₁₃FN₂O₂
Molecular Weight	236.24 g/mol
Synonyms	2-tert-Butyl-4-fluoro-5-nitro-1H-indole; 4-Fluoro-5-nitro-2-(tert-butyl)-1H-indole; 1H-Indole, 2-(1,1-dimethylethyl)-4-fluoro-5-nitro-; 2-(tert-Butyl)-4-fluoro-5-nitroindole; 952664-90-3; 2-tert-Butyl-4-fluoro-5-nitroindole
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl-4-Fluoro-5-Nitro-1H-Indole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.