Description

3-(2-Chloro-2-Oxoacetyl)-1H-Indol-4-Yl Acetate is a high-purity, synthetically valuable indole derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex indole-based drug candidates, particularly in oncology and CNS research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under GMP or non-GMP conditions.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies due to its reactive chloro-oxoacetyl moiety.
• Custom Synthesis: Foundation for the custom manufacturing of more complex, target-specific molecules for client R&D projects.

Basic Information

Product Name	3-(2-Chloro-2-Oxoacetyl)-1H-Indol-4-Yl Acetate
CAS No.	952006-34-7
Molecular Formula	C₁₂H₈ClNO₄
Molecular Weight	265.65 g/mol
Synonyms	4-Acetoxy-3-(2-chloro-2-oxoacetyl)indole; 1H-Indol-4-ol, 3-(chlorooxoacetyl)-, acetate; 3-(Chloroglyoxyloyl)-1H-indol-4-yl acetate; 4-Acetoxyindole-3-glyoxyloyl chloride; 3-(2-Chloro-2-oxoacetyl)-4-indolyl acetate; 4-(Acetyloxy)-3-(2-chloro-2-oxoacetyl)-1H-indole
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-2-Oxoacetyl)-1H-Indol-4-Yl Acetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.