Description

1-Hydroxy-6-(Trifluoromethyl)Indolin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique indolinone scaffold substituted with a hydroxyl and a trifluoromethyl group. This compound matters for its critical role in the synthesis of novel bioactive molecules, particularly in medicinal chemistry where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs targeting complex diseases.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of novel drug candidates, especially those targeting protein kinases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and pharmacokinetic properties of lead compounds.
• Chemical Synthesis: Serves as a versatile precursor for the synthesis of more complex heterocyclic compounds and functionalized indolinones.
• Agrochemical Development: Potential application in the synthesis of new active ingredients for crop protection products.
• Material Science: Exploration of use in the synthesis of specialty chemicals and functional materials.

Basic Information

Product Name	1-Hydroxy-6-(Trifluoromethyl)Indolin-2-One
CAS No.	951883-90-2
Molecular Formula	C9H6F3NO2
Molecular Weight	217.15 g/mol
Synonyms	1-Hydroxy-6-(trifluoromethyl)-2-indolinone; 6-(Trifluoromethyl)-1H-indole-2,3-dione, 1-hydroxy-; 1-Hydroxy-6-(trifluoromethyl)indoline-2,3-dione; 1-Hydroxy-6-trifluoromethylindolin-2-one; 951883-90-2; 6-Trifluoromethyl-1-hydroxyindolin-2-one
EINECS	Contact for details

Quality Control

Our 1-Hydroxy-6-(Trifluoromethyl)Indolin-2-One is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. This product is light-sensitive and should be stored away from light as indicated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.