Description

1H-Pyrrole-3-Carboxylic Acid, 5-(2-Amino-4-Pyrimidinyl)-2-(1-Methyl-1H-Indol-2-Yl)- is a high-purity, complex heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring fused pyrrole, pyrimidine, and indole rings, makes it an invaluable intermediate for pharmaceutical research and development. This compound is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active pharmaceutical ingredients (APIs) and exploring new therapeutic modalities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Kinase Inhibitor Research: Serves as a core scaffold for the development of selective kinase inhibitors due to its pyrimidine and indole motifs.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying enzyme function and cellular signaling pathways.
• Agrochemical Development: Potential intermediate for creating new generation herbicides or fungicides with novel modes of action.
• Material Science Research: Investigated as a monomer or dopant for creating specialized conductive polymers or organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting custom synthesis and scale-up projects for global clients.

Basic Information

Product Name	1H-Pyrrole-3-Carboxylic Acid, 5-(2-Amino-4-Pyrimidinyl)-2-(1-Methyl-1H-Indol-2-Yl)-
CAS No.	951784-35-3
Molecular Formula	C18H15N5O2
Molecular Weight	333.35 g/mol
Synonyms	5-(2-Aminopyrimidin-4-yl)-2-(1-methyl-1H-indol-2-yl)-1H-pyrrole-3-carboxylic acid; 2-(1-Methyl-1H-indol-2-yl)-5-(2-aminopyrimidin-4-yl)-1H-pyrrole-3-carboxylic acid; 951784-35-3; 4-Pyrimidinamine, 2-[3-carboxy-5-(1-methyl-1H-indol-2-yl)-1H-pyrrol-2-yl]-; Pyrrole-3-carboxylic acid derivative (CAS 951784-35-3); Advanced heterocyclic building block 951784-35-3
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrole-3-Carboxylic Acid, 5-(2-Amino-4-Pyrimidinyl)-2-(1-Methyl-1H-Indol-2-Yl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all test results are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.