Description

tert-Butyl 4-(5-Methoxy-1H-Indol-3-Yl)-1-Piperidinecarboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of complex molecules targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in the production of novel active pharmaceutical ingredients (APIs). The precise structure of this intermediate allows for the efficient construction of pharmacologically active indole-piperidine derivatives.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent serotonin receptor modulators and other neuroactive compounds.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• API Synthesis: Integral building block for constructing complex molecular scaffolds in the final stages of Active Pharmaceutical Ingredient (API) manufacturing.
• Biochemical Research: Employed as a reference standard or a tool compound in pharmacological assays and biochemical screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and methodological development.

Basic Information

Product Name	tert-Butyl 4-(5-Methoxy-1H-Indol-3-Yl)-1-Piperidinecarboxylate
CAS No.	951174-11-1
Molecular Formula	C19H26N2O3
Molecular Weight	330.43 g/mol
Synonyms	1-Boc-4-(5-Methoxy-1H-indol-3-yl)piperidine; tert-Butyl 4-(5-methoxy-1H-indol-3-yl)piperidine-1-carboxylate; 4-(5-Methoxy-1H-indol-3-yl)-1-piperidinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(5-methoxy-1H-indol-3-yl)piperidine; 951174-11-1; Boc-4-(5-MeO-indol-3-yl)piperidine; 4-(5-Methoxyindol-3-yl)-1-N-Boc-piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Methoxy-1H-Indol-3-Yl)-1-Piperidinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical intermediates, supporting both research and cGMP-grade production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.