Description

Timapiprant Sodium is a high-purity, small molecule active pharmaceutical ingredient (API) with the CAS registry number 950688-14-9. This compound is a selective antagonist of the prostaglandin D2 receptor 2 (DP2/CRTH2), making it a critical intermediate for advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of novel therapeutics for inflammatory and allergic conditions, such as asthma, allergic rhinitis, and atopic dermatitis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of final drug formulations targeting the DP2/CRTH2 pathway.
• Preclinical & Clinical Research: Used in in vitro and in vivo studies to investigate the efficacy and mechanisms of DP2/CRTH2 antagonism.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Drug Discovery Programs: Integral to medicinal chemistry efforts for optimizing lead compounds in immunology and respiratory disease pipelines.
• Process Chemistry Development: Used to scale up and optimize synthetic routes for commercial-scale API production.

Basic Information

Product Name	Timapiprant Sodium
CAS No.	950688-14-9
Molecular Formula	C23H22F3N3O3Na
Molecular Weight	480.43 g/mol
Synonyms	Timapiprant Sodium Salt; ACT-129968 Sodium; 4-[(5-Fluoro-2-{[4-(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)phenyl]amino}phenyl)methyl]-4-oxobutanoic Acid Sodium Salt; (2Z)-2-{3-[(5-Fluoro-2-{[4-(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)phenyl]amino}phenyl)methyl]-4-oxo-1,3-thiazolidin-2-ylidene}acetic Acid (Alternative IUPAC); ACT-129968 (Free Acid); CRTH2 Antagonist ACT-129968 Sodium; DP2 Receptor Antagonist Sodium Salt
EINECS	Contact for details

Quality Control

Our Timapiprant Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.