Description

(S)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Ethyl Ester is a high-value chiral building block and intermediate of significant importance in modern synthetic organic chemistry. Its core value lies in its stereochemically defined tetrahydroisoquinoline scaffold, which is a privileged structure in medicinal chemistry for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and fine chemicals requiring precise chirality.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of drug candidates targeting neurological disorders, cardiovascular diseases, and oncology.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to introduce the tetrahydroisoquinoline moiety with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Intermediate in the synthesis of advanced, chiral pesticides and herbicides.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and catalysis at universities and research institutions.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Ethyl Ester
CAS No.	950580-38-8
Molecular Formula	C₁₂H₁₅NO₂
Molecular Weight	205.25 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid ethyl ester; Ethyl (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylate; (S)-1-Carbethoxy-1,2,3,4-tetrahydroisoquinoline; (S)-1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic Acid Ethyl Ester; (S)-Tic-OEt; (S)-ETIQ; L-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.