Description

tert-Butyl 3-Bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated imidazopyrazine core protected by a tert-butyloxycarbonyl (Boc) group. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics, particularly for central nervous system (CNS) and oncology applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile bromine handle for further functionalization.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• CNS Drug Development: The imidazopyrazine scaffold is of significant interest for developing therapeutics for neurological disorders.
• Kinase Inhibitor Synthesis: Acts as a building block for potential kinase inhibitors, a major class in oncology and inflammatory disease research.
• Process Chemistry & Scale-up: Suitable for use in route development and pilot-scale synthesis under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	tert-Butyl 3-Bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate
CAS No.	949922-61-6
Molecular Formula	C11H16BrN3O2
Molecular Weight	302.17 g/mol
Synonyms	3-Bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine; 7-Boc-3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine; tert-Butyl 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-7-carboxylate; 3-Bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylic acid tert-butyl ester; BOC-3-Bromo-DHIP; 949922-61-6; 3-Bromo-7-Boc-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-Bromo-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research and development. All materials undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, supporting compliance with internal quality management systems and regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.