Description

Methanone, (6,7-Diethoxy-3,4-Dihydro-2(1H)-Isoquinolinyl)[6-(Trifluoromethyl)-3-Pyridinyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating both isoquinoline and pyridine motifs. This compound matters for its critical role as a sophisticated building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and other therapeutic areas. Research institutions, custom synthesis houses, and pharmaceutical development companies need this material to accelerate drug discovery and process development programs.

Application

• Pharmaceutical Intermediate: Key building block for the research and development of new drug candidates, especially in neurological and psychiatric therapeutic areas.
• Organic Synthesis Reagent: Used in complex multi-step syntheses to construct intricate molecular architectures due to its functionalized isoquinoline and pyridine rings.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for potential API manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Item	Details
Product Name	Methanone, (6,7-Diethoxy-3,4-Dihydro-2(1H)-Isoquinolinyl)[6-(Trifluoromethyl)-3-Pyridinyl]-
CAS No.	949867-67-8
Molecular Formula	C22H23F3N2O3
Molecular Weight	420.43 g/mol
Synonyms	(6,7-Diethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)[6-(trifluoromethyl)pyridin-3-yl]methanone; 1-(6,7-Diethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-[6-(trifluoromethyl)pyridin-3-yl]ethanone (tautomeric form); 949867-67-8; (6,7-Diethoxy-3,4-dihydro-2(1H)-isoquinolinyl)[6-(trifluoromethyl)-3-pyridinyl]methanone; CAS 949867-67-8
EINECS	Contact for details

Quality Control

Our Methanone, (6,7-Diethoxy-3,4-Dihydro-2(1H)-Isoquinolinyl)[6-(Trifluoromethyl)-3-Pyridinyl]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request, supporting compliance with cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.