Description

Succinimidyl 4-[3,5-Dimethyl-4-(4-Nitrobenzyloxy)Phenyl]-4-Oxobutyrate is a specialized, high-purity chemical intermediate designed for advanced bioconjugation and crosslinking applications. Its core value lies in its activated ester group, which enables efficient and selective coupling to primary amines under mild conditions, forming stable amide bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and life science sectors who require reliable and precise reagents for developing antibody-drug conjugates (ADCs), protein labeling, and surface functionalization.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: A key building block for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Used to attach fluorescent dyes, biotin, or other reporter molecules to proteins for detection, imaging, and assay development.
• Surface Functionalization: Enables the covalent immobilization of biomolecules onto sensor chips, nanoparticles, or microplates for biosensor and diagnostic device manufacturing.
• Polymer Modification: Facilitates the introduction of amine-reactive groups into polymer backbones for creating functional biomaterials and drug delivery systems.
• Crosslinking Agent: Serves as a homobifunctional crosslinker for studying protein-protein interactions or stabilizing molecular complexes.
• Small Molecule Prodrug Development: Utilized to create targeted prodrugs by linking therapeutic agents to targeting ligands.

Basic Information

Product Name	Succinimidyl 4-[3,5-Dimethyl-4-(4-Nitrobenzyloxy)Phenyl]-4-Oxobutyrate
CAS No.	948995-62-8
Molecular Formula	C23H22N2O8
Molecular Weight	454.43 g/mol
Synonyms	4-[3,5-Dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyric acid N-hydroxysuccinimide ester; 4-(N-Succinimidyloxycarbonyl)-3,5-dimethyl-4'-(4-nitrobenzyloxy)benzophenone; NHS ester of 4-[3,5-Dimethyl-4-(4-nitrobenzyloxy)phenyl]-4-oxobutyric acid; 948995-62-8; 4-(3,5-Dimethyl-4-((4-nitrophenyl)methoxy)phenyl)-4-oxobutanoic acid 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our Succinimidyl 4-[3,5-Dimethyl-4-(4-Nitrobenzyloxy)Phenyl]-4-Oxobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation work. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.