Description

1-Acetylimidazole is a versatile and highly reactive acetylating agent, primarily used for the selective modification of amino and hydroxyl groups in complex molecules. Its value lies in its ability to act as a mild and specific acetyl donor under controlled conditions, making it indispensable for precise chemical synthesis and biochemical research. This compound is critically needed by pharmaceutical R&D teams for drug intermediate synthesis, by biochemists for protein and enzyme studies, and by fine chemical manufacturers producing specialized reagents.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the acetylation of nucleosides, amino acids, and other sensitive drug precursors.
• Biochemical Research: Selective acetylation of specific amino acid residues (e.g., lysine, serine) in peptides, proteins, and enzymes to study structure-function relationships.
• Polymer Chemistry: Used in the modification of polymers and the synthesis of functional monomers containing imidazole or acetyl groups.
• Catalyst and Ligand Preparation: Serves as a precursor for synthesizing N-heterocyclic carbene (NHC) ligands and other organocatalysts.
• Fine Chemical Production: Manufacture of specialized acetylated derivatives used in agrochemicals, dyes, and photographic chemicals.
• Analytical Chemistry: Derivatization agent for the analysis of compounds containing active hydrogen atoms via spectroscopic methods.

Basic Information

Product Name	1-Acetylimidazole
CAS No.	2466-76-4
Molecular Formula	C5H6N2O
Molecular Weight	110.11 g/mol
Synonyms	N-Acetylimidazole; 1H-Imidazole, 1-acetyl-; Imidazole, 1-acetyl-; Acetylimidazole; N-Acetyl-1H-imidazole; Acetic acid imidazolide; 1-Acetyl-1H-imidazole; NSC 406085
EINECS	219-560-1

Quality Control

Our 1-Acetylimidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can lead to decomposition. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	101 - 105 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.