Description

Diethyl Malonimidate Dihydrochloride is a versatile bifunctional cross-linking reagent, primarily used for the chemical modification of proteins and other biomolecules. This compound matters for its ability to introduce stable covalent bonds under mild conditions, which is crucial for advanced biochemical research and bioconjugation strategies. It is needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications ranging from antibody-drug conjugate (ADC) development to enzyme immobilization and material science.

Application

• Bioconjugation and Protein Cross-linking: A key reagent for covalently linking proteins, peptides, or antibodies to other molecules, surfaces, or carriers.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs for targeted cancer therapies.
• Enzyme and Protein Immobilization: Facilitates the stable attachment of bioactive proteins to solid supports for biosensors, diagnostic assays, and industrial biocatalysis.
• Biomaterial Modification: Employed to functionalize polymers, nanoparticles, and hydrogels with amine-reactive groups to enhance biocompatibility or introduce specific ligands.
• Affinity Chromatography Ligand Synthesis: Used to prepare immobilized ligands for the purification of specific proteins or biomolecules.
• Structural Biology Studies: Applied in probing protein structure, interactions, and dynamics through cross-linking mass spectrometry (XL-MS).

Basic Information

Product Name	Diethyl Malonimidate Dihydrochloride
CAS No.	10344-69-1
Molecular Formula	C7H12N2O2 · 2HCl
Molecular Weight	241.10 g/mol
Synonyms	Diethyl Malonimidate Dihydrochloride; Diethyl Malonimidate Hydrochloride; Diethyl Malonimidate HCl; Diethyl Malonate Imidate Dihydrochloride; 3,3-Diethoxy-2-azaprop-2-en-1-iminium Dihydrochloride; Diethyl Malonimidate, Dihydrochloride Salt; Malonimidic Acid Diethyl Ester Dihydrochloride; Ethyl Malonimidate Dihydrochloride
EINECS	Contact for details

Quality Control

Our Diethyl Malonimidate Dihydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support our global customer base in pharmaceutical and biotech industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.