Description

n-(Benzyloxycarbonyloxy)succinimide (CAS NO 13139-17-8) is a highly reactive and versatile carbamate-activating reagent used extensively in organic synthesis and peptide chemistry. Its primary value lies in its ability to efficiently introduce the benzyloxycarbonyl (Cbz or Z) protecting group onto amines, a critical step for controlling regioselectivity in complex molecule assembly. This compound is an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for the development of APIs, peptides, and other high-value intermediates.

Application

• Peptide Synthesis: As a key reagent for introducing the Cbz (Z) protecting group onto amino acids and peptide fragments during solid-phase and solution-phase synthesis.
• Pharmaceutical Intermediate Manufacturing: Used in the synthesis of active pharmaceutical ingredients (APIs) where amine protection is required to prevent unwanted side reactions.
• Organic Compound Derivatization: Employed to protect amine functionalities in the synthesis of complex natural products, alkaloids, and other specialty organic molecules.
• Bioconjugation Chemistry: Facilitates the controlled modification of proteins, antibodies, or other biomolecules by selectively attaching functional groups via amine linkages.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialized polyamides or polymers with tailored amine functionalities.
• Chemical Research & Development: A standard tool in medicinal chemistry and process R&D labs for exploring new synthetic pathways and protecting group strategies.

Basic Information

Product Name	n-(Benzyloxycarbonyloxy)succinimide
CAS No.	13139-17-8
Molecular Formula	C12H11NO5
Molecular Weight	249.22 g/mol
Synonyms	N-Carbobenzoxysuccinimide; N-(Benzyloxycarbonyloxy)succinimide; Z-OSu; Cbz-OSu; Benzyl N-succinimidyl carbonate; Succinimidyl benzyl carbonate; NSC 3346; Benzyloxycarbonyloxysuccinimide; N-(Benzyloxycarbonyl)oxysuccinimide
EINECS	Contact for details

Quality Control

Every batch of our n-(Benzyloxycarbonyloxy)succinimide is produced and tested under a strict quality management system. We ensure high chemical purity and lot-to-lot consistency through comprehensive analytical protocols, including HPLC, NMR, and melting point determination. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specified parameters. Our quality commitment supports applications requiring reliable and reproducible synthetic results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions (e.g., nitrogen or argon atmosphere) to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.