Description

1,4-Bis(2,2,2-Trichloro-1-Formamidoethyl)Piperazine-D8 is a high-purity, deuterated isotopologue of a specialized piperazine derivative, serving as a critical internal standard and reference material in advanced analytical chemistry. Its primary value lies in enabling precise quantification and method validation in complex matrices, eliminating interference from non-deuterated species. This compound is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental testing sectors, where accurate mass spectrometry and NMR analysis are paramount for drug metabolism studies, residue analysis, and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of its non-deuterated counterpart or related analogs in bioanalytical methods for pharmacokinetic and metabolism studies.
• Metabolite Identification & Tracing: Employed in drug discovery and development to trace metabolic pathways and identify degradation products using high-resolution mass spectrometry.
• Environmental Analysis: Serves as a reference standard in the detection and quantification of persistent organic pollutants or pesticide residues in environmental samples.
• Quality Control & Method Validation: Critical for validating analytical procedures in pharmaceutical quality control labs, ensuring accuracy, precision, and regulatory compliance (e.g., ICH guidelines).
• NMR Spectroscopy: Utilized as a deuterated probe in nuclear magnetic resonance studies to investigate molecular structure and dynamics without signal interference from protons.
• Stable Isotope Labeling Studies: Applied in mechanistic studies and proteomics research to track the incorporation and fate of specific molecular fragments.

Basic Information

Product Name	1,4-Bis(2,2,2-Trichloro-1-Formamidoethyl)Piperazine-D8
CAS No.	948595-12-8
Molecular Formula	C10H4D8Cl6N4O2
Molecular Weight	Contact for details
Synonyms	1,4-Bis(2,2,2-Trichloroacetamidoethyl)piperazine-D8; 1,4-Bis(2,2,2-Trichloro-1-oxoethylaminoethyl)piperazine-D8; N,N'-Bis(2,2,2-Trichloro-1-oxoethyl)piperazine-1,4-diethanamine-D8; Deuterated Trichloroacetylpiperazine Derivative; TCAE-Piperazine-D8; 948595-12-8 (CAS Index Name); 1,4-Piperazinediethanamine, N,N'-bis(2,2,2-trichloroacetyl)-, d8
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems. Each batch of 1,4-Bis(2,2,2-Trichloro-1-Formamidoethyl)Piperazine-D8 undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm isotopic purity, chemical purity, and identity. Certificates of Analysis (COA) detailing batch-specific results are provided and traceable to relevant standards. We support compliance needs for GLP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.