Description

2-(Difluoromethoxy)-Benzeneboronic Acid is a specialized organoboron compound featuring a difluoromethoxy substituent on the aromatic ring, which significantly influences its reactivity and physical properties. This structural motif makes it a valuable high-purity building block for modern synthetic chemistry, particularly in cross-coupling reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the stability of the boronic acid group.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials and polymers.
• Ligand and Catalyst Development: Employed to create novel ligands for transition metal catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D projects.

Basic Information

Product Name	2-(Difluoromethoxy)-Benzeneboronic Acid
CAS No.	947533-11-1
Molecular Formula	C7H7BF2O3
Molecular Weight	187.94 g/mol
Synonyms	2-(Difluoromethoxy)phenylboronic Acid; [2-(Difluoromethoxy)phenyl]boronic Acid; Benzeneboronic Acid, 2-(difluoromethoxy)-; 2-Difluoromethoxyphenylboronic Acid; o-(Difluoromethoxy)phenylboronic Acid; (2-(Difluoromethoxy)phenyl)boronic Acid; Boronic Acid, B-[2-(difluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.