Description

tert-Butyl 4-(1H-Indazol-3-Yl)Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in oncology and central nervous system (CNS) research. It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers engaged in the development of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent kinase inhibitors and other targeted cancer therapies.
• Drug Discovery Scaffold: Used as a core structural motif for constructing compound libraries in high-throughput screening (HTS) campaigns.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead drug candidates.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Biochemical Tool Compound: Utilized in biochemical assays to study specific enzyme pathways and biological mechanisms.
• Custom Synthesis Projects: Serves as a starting material for bespoke chemical synthesis for specialized research programs.

Basic Information

Product Name	tert-Butyl 4-(1H-Indazol-3-Yl)Piperazine-1-Carboxylate
CAS No.	947498-81-9
Molecular Formula	C16H22N4O2
Molecular Weight	302.37 g/mol
Synonyms	1-Boc-4-(1H-indazol-3-yl)piperazine; tert-Butyl 4-(1H-indazol-3-yl)piperazine-1-carboxylate; 4-(1H-Indazol-3-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(1H-indazol-3-yl)piperazine; 3-(1-Boc-piperazin-4-yl)-1H-indazole; BOC-4-(1H-Indazol-3-yl)piperazine; 947498-81-9; 1H-Indazole-3-piperazine, 1-BOC-protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(1H-Indazol-3-Yl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.