Description

tert-Butyl 2-bromo-1,3-thiazole-4-carboxylate is a high-purity, versatile heterocyclic building block essential for advanced organic synthesis. This compound is particularly valued for its reactive bromine and carboxylate ester functionalities, which enable efficient derivatization and incorporation into complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other bioactive heterocycles.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging the thiazole core for biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its modifiable aromatic structure.
• Chemical Biology & Proteomics: Employed as a building block for creating chemical probes, affinity tags, and linkers used in bioconjugation and target identification studies.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl and other complex structures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of client-specific target molecules.

Basic Information

Product Name	tert-Butyl 2-Bromo-1,3-Thiazole-4-Carboxylate
CAS No.	947407-89-8
Molecular Formula	C8H10BrNO2S
Molecular Weight	264.14 g/mol
Synonyms	2-Bromo-1,3-thiazole-4-carboxylic acid tert-butyl ester; 4-(tert-Butoxycarbonyl)-2-bromothiazole; tert-Butyl 2-bromothiazole-4-carboxylate; 2-Bromo-4-(tert-butoxycarbonyl)thiazole; 1,3-Thiazole-4-carboxylic acid, 2-bromo-, 1,1-dimethylethyl ester; TBTC; 2-Bromothiazole-4-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-bromo-1,3-thiazole-4-carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.