Description

n-(1,1,2,2-Tetradeuterio-2-Hydroxyethyl)Hexadecanamide is a deuterated analog of palmitoylethanolamide (PEA), a bioactive lipid mediator. This compound is specifically engineered for research and development applications where isotopic labeling is required for advanced analytical studies, such as mass spectrometry and metabolic pathway tracing. It is primarily utilized by pharmaceutical R&D laboratories, analytical chemistry service providers, and academic institutions focused on lipidomics, endocannabinoid system research, and drug discovery.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical deuterated internal standard for the precise quantification of endogenous palmitoylethanolamide (PEA) in biological matrices via LC-MS/MS.
• Metabolic Pathway Tracing: Used in pharmacokinetic and metabolic studies to track the absorption, distribution, metabolism, and excretion (ADME) of PEA and related compounds.
• Lipidomics Research: A key reagent in lipidomic profiling to study the role of fatty acid amides in cellular signaling, inflammation, and neurological functions.
• Pharmaceutical R&D: Employed in the development and validation of bioanalytical methods for novel therapeutics targeting the endocannabinoid system.
• Reference Standard: Provides a high-purity certified reference material for calibrating analytical instruments and ensuring data accuracy in regulatory submissions.
• Biochemical Assay Development: Used to create robust in-vitro assays for screening compounds that modulate fatty acid amide hydrolase (FAAH) or other enzymes in the N-acylethanolamine pathway.

Basic Information

Product Name	n-(1,1,2,2-Tetradeuterio-2-Hydroxyethyl)Hexadecanamide
CAS No.	946524-34-1
Molecular Formula	C18H33D4NO2
Molecular Weight	303.51 g/mol (for C18H33D4NO2)
Synonyms	Deuterated Palmitoylethanolamide; d4-PEA; N-(2-Hydroxyethyl)hexadecanamide-d4; Palmitoylethanolamide-d4; N-Hexadecanoyl-d4-ethanolamine; PEA-d4; 2-[(1,1,2,2-Tetradeuterio-2-hydroxyethyl)amino]-1-hexadecanone; Deuterium Labeled PEA
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR (for deuterium incorporation), HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing assay purity, isotopic enrichment, and impurity profiles. We support compliance with GLP (Good Laboratory Practice) standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment after each use to prevent degradation. For short-term use (under one week), storage at 2-8°C is acceptable.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.