Description

Methyl 4-Fluoro-3-(Morpholine-4-Sulfonyl)-1-Benzothiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a benzothiophene core functionalized with fluorine and a morpholine sulfonyl group. This compound matters for its critical role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry research and development. Pharmaceutical companies, contract research organizations (CROs), and fine chemical manufacturers need it for developing new drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially those with benzothiophene scaffolds.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved potency and selectivity.
• Protease Inhibitor Development: The morpholine sulfonyl moiety suggests potential application in the design of inhibitors for various protease enzymes.
• Kinase Inhibitor Synthesis: Employed in the research and development of kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects, from milligram-scale research to kilogram-scale pilot production for clinical trials.

Basic Information

Item	Detail
Product Name	Methyl 4-Fluoro-3-(Morpholine-4-Sulfonyl)-1-Benzothiophene-2-Carboxylate
CAS No.	946300-74-9
Molecular Formula	C14H14FNO5S2
Molecular Weight	359.39 g/mol
Synonyms	4-Fluoro-3-(morpholinosulfonyl)-1-benzothiophene-2-carboxylic acid methyl ester; Methyl 4-fluoro-3-(4-morpholinesulfonyl)benzo[b]thiophene-2-carboxylate; Methyl 4-fluoro-3-(morpholine-4-sulfonyl)-1-benzothiophene-2-carboxylate; 946300-74-9; 1-Benzothiophene-2-carboxylic acid, 4-fluoro-3-(4-morpholinylsulfonyl)-, methyl ester; MFCD22586667; 4-Fluoro-3-(morpholine-4-sulfonyl)benzo[b]thiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Fluoro-3-(Morpholine-4-Sulfonyl)-1-Benzothiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere or with desiccant for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.