Description

1-[tert-Butyl(Dimethyl)Silyl]-5-Indolecarboxaldehyde is a high-value, protected indole derivative used as a versatile synthetic intermediate in advanced organic chemistry. Its core value proposition lies in providing a reactive aldehyde functionality while the tert-butyldimethylsilyl (TBDMS) group protects the indole nitrogen, enabling selective and complex multi-step synthesis. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that utilize the indole scaffold.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and conductive polymers.
• Academic & R&D Laboratories: A critical reagent for methodological studies in organic synthesis, including cross-coupling reactions and heterocyclic chemistry.
• Peptidomimetic Development: Employed in the design and synthesis of indole-containing peptide analogs for biochemical research.

Basic Information

Product Name	1-[tert-Butyl(Dimethyl)Silyl]-5-Indolecarboxaldehyde
CAS No.	946077-36-7
Molecular Formula	C₁₅H₂₁NO₂Si
Molecular Weight	275.42 g/mol
Synonyms	5-Formyl-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole; 1H-Indole-5-carboxaldehyde, 1-[(1,1-dimethylethyl)dimethylsilyl]-; 1-(tert-Butyldimethylsilyl)-1H-indole-5-carbaldehyde; 1-TBDMS-indole-5-carboxaldehyde; N-TBDMS-5-indolecarboxaldehyde; 5-Indolecarboxaldehyde, 1-[tert-butyl(dimethyl)silyl]-; N-tert-Butyldimethylsilyl-5-indolecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 1-[tert-Butyl(Dimethyl)Silyl]-5-Indolecarboxaldehyde is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.