Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 5-Fluoro-1-(Phenylmethyl)-, Ethyl Ester is a high-purity fluorinated pyrrolopyridine derivative, a crucial advanced pharmaceutical intermediate. Its value lies in its role as a sophisticated building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapies. This compound is essential for research and development chemists and process scale-up teams within the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of kinase inhibitors and other targeted small-molecule drugs.
• Oncology Research: Used in the discovery and synthesis of novel anti-cancer compounds due to its privileged pyrrolopyridine scaffold.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-up: Employed in the development of robust, scalable synthetic routes for API manufacturing under cGMP conditions.
• Biochemical Research: Used as a tool compound or ligand in biochemical assays and proteomics studies.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for client-specific API synthesis projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 5-Fluoro-1-(Phenylmethyl)-, Ethyl Ester
CAS No.	945912-77-6
Molecular Formula	C₁₇H₁₅FN₂O₂
Molecular Weight	298.31 g/mol
Synonyms	5-Fluoro-1-benzyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; Ethyl 5-fluoro-1-(phenylmethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate; 1-Benzyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; 5-Fluoro-1-benzyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester; 945912-77-6; 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-fluoro-1-(phenylmethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid, 5-Fluoro-1-(Phenylmethyl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports development from research to commercial scale, with documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.