Description

1-(4-Amino-Butyl)-Pyrrole-2,5-Dione is a specialized heterocyclic building block featuring both a primary amine and a maleimide (pyrrole-2,5-dione) functional group. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily utilized by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for creating targeted conjugates, polymers, and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and antibody-drug conjugates (ADCs), leveraging its amine for linkage and maleimide for thiol-specific conjugation.
• Bioconjugation Reagent: Used to functionalize proteins, peptides, and antibodies for diagnostic assays, targeted drug delivery systems, and biochemical probes.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polymers, hydrogels, and functionalized materials with tailored properties.
• Chemical Biology & Proteomics: Employed in activity-based protein profiling (ABPP) and the development of covalent inhibitors or affinity tags.
• Material Science: Used to modify surface properties and create advanced coatings or adhesives with specific chemical functionalities.
• Research & Development: A versatile scaffold in medicinal chemistry for exploring new drug candidates and biological pathways.

Basic Information

Product Name	1-(4-Amino-Butyl)-Pyrrole-2,5-Dione
CAS No.	945530-68-7
Molecular Formula	C8H12N2O2
Molecular Weight	168.19 g/mol
Synonyms	4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)butan-1-amine; N-(4-Aminobutyl)maleimide; 1-(4-Aminobutyl)-1H-pyrrole-2,5-dione; Maleimide-PEG4-amine (core structure); 4-Aminobutylmaleimide; Aminobutylmaleimide; Butylamine maleimide derivative
EINECS	Contact for details

Quality Control

Our 1-(4-Amino-Butyl)-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.