Description

n-Phthaloyl-Dl-Glutamic Anhydride is a versatile chiral building block and protected amino acid derivative used in advanced organic synthesis. This compound is critical for the controlled introduction of glutamic acid moieties into peptide chains and other complex molecules, enabling precise structural modifications. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and fine chemical intermediates. Its role in facilitating asymmetric synthesis makes it a valuable asset for chemists focused on creating high-value, optically active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Serves as a protected glutamic acid derivative for the solid-phase and solution-phase synthesis of peptides and peptidomimetics.
• Chiral Building Block: Utilized in asymmetric synthesis to construct optically active compounds for medicinal chemistry and material science.
• Bioconjugation Chemistry: Employed in the modification of biomolecules, such as proteins and antibodies, for research and diagnostic applications.
• Academic & Industrial Research: Used in R&D laboratories for exploring new synthetic methodologies and developing novel chemical entities.
• Fine Chemical Production: Integral in the multi-step synthesis of specialty chemicals, flavors, and fragrances.

Basic Information

Product Name	n-Phthaloyl-Dl-Glutamic Anhydride
CAS No.	3343-28-0
Molecular Formula	C₁₃H₉NO₅
Molecular Weight	259.22 g/mol
Synonyms	DL-2-Phthalimidoglutaric Anhydride; N-Phthaloyl-DL-glutamic Acid Anhydride; 2-(1,3-Dioxoisoindolin-2-yl)pentanedioic Anhydride; Phthaloyl-DL-glutamic Anhydride; PGAn; Phthalimidoglutaric Anhydride; N-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)glutamic Anhydride; DL-N-Phthaloylglutamic Anhydride
EINECS	222-108-3

Quality Control

Our n-Phthaloyl-Dl-Glutamic Anhydride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, IR for identification, and loss on drying for moisture content. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP guidelines for pharmaceutical intermediates and can tailor specifications to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158°C - 165°C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Optical Purity (Enantiomeric Excess)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.