Description

n-Hydroxymaleimide is a versatile heterocyclic compound featuring a reactive maleimide core substituted with a hydroxyl group. This unique structure makes it a valuable bifunctional building block for synthesizing advanced polymers, pharmaceutical intermediates, and specialty chemicals. It is particularly sought after by R&D and production teams in the pharmaceutical, polymer science, and agrochemical industries for creating cross-linked materials, bioactive conjugates, and novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly for creating maleimide-based drug conjugates.
• Polymer Cross-linking Agent: Utilized to introduce cross-links into polymer chains, enhancing thermal stability, mechanical strength, and chemical resistance in specialty resins and coatings.
• Bioconjugation Chemistry: Acts as a linker for attaching peptides, proteins, or fluorescent dyes to carriers, crucial for developing diagnostic assays and targeted therapeutics.
• Agrochemical Synthesis: Employed in the production of advanced pesticides and herbicides, where its reactive imide ring can be functionalized to create novel bioactive molecules.
• Material Science Research: Used in academic and industrial R&D to develop new functional materials, such as self-healing polymers or smart hydrogels.
• Organic Synthesis Reagent: Functions as a dienophile in Diels-Alder reactions and as an electrophile in Michael additions, enabling complex molecular construction.

Basic Information

Product Name	n-Hydroxymaleimide
CAS No.	4814-74-8
Molecular Formula	C4H3NO3
Molecular Weight	113.07 g/mol
Synonyms	1-Hydroxymaleimide; 1-Hydroxy-1H-pyrrole-2,5-dione; Maleimide, N-hydroxy-; N-Hydroxymaleinimide; HMI; N-Hydroxy-2,5-pyrroledione; 2,5-Dihydroxypyrrole-2,5-dione (tautomer); N-Hydroxymaleic acid imide
EINECS	225-389-7

Quality Control

Our n-Hydroxymaleimide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets precise specifications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	138°C - 142°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.