Description

7-Amino-5-Fluoroindolin-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its unique indolinone core structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted small-molecule therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing indole and indolinone-based scaffolds with potential biological activity.
• Research & Development (R&D): Essential for academic and industrial R&D labs exploring new chemical entities (NCEs) and structure-activity relationships (SAR).
• Agrochemical Intermediates: Potential use in the development of new generation herbicides and pesticides with fluorinated active ingredients.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	7-Amino-5-Fluoroindolin-2-One
CAS No.	945381-62-4
Molecular Formula	C8H7FN2O
Molecular Weight	166.15 g/mol
Synonyms	5-Fluoro-7-aminoindolin-2-one; 2H-Indol-2-one, 7-amino-5-fluoro-1,3-dihydro-; 7-Amino-5-fluoro-1,3-dihydro-2H-indol-2-one; 5-Fluoro-7-aminooxindole; 7-Amino-5-fluorooxindole; 5-Fluoro-7-amino-2-indolinone; 7-Amino-5-fluoro-2-indolinone; 945381-62-4
EINECS	Contact for details

Quality Control

Our 7-Amino-5-Fluoroindolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.