Description

7-Bromo-5-Fluoro-1,3-Dihydro-Indol-2-One is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound serves as a critical building block in the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Organic Synthesis Building Block: Employed in the construction of complex heterocyclic compounds due to its reactive bromo and fluoro substituents on the indolinone core.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents and pesticides.
• Material Science: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	7-Bromo-5-Fluoro-1,3-Dihydro-Indol-2-One
CAS No.	945379-34-0
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	7-Bromo-5-fluoroindolin-2-one; 5-Fluoro-7-bromo-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 7-bromo-5-fluoro-1,3-dihydro-; 7-Bromo-5-fluorooxindole; 945379-34-0; 7-Br-5-F-indolin-2-one
EINECS	Contact for details

Quality Control

Our 7-Bromo-5-Fluoro-1,3-Dihydro-Indol-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC, NMR, and mass spectrometry, to verify identity and purity. Certificates of Analysis (COA) are available for every batch and provided upon request, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.