Description

3-(2-Chloropyrimidin-4-Yl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate featuring a versatile indole-pyrimidine scaffold. This compound matters as a critical building block for the synthesis of targeted small molecule therapeutics, particularly kinase inhibitors. Pharmaceutical R&D and fine chemical synthesis companies need it for developing new drug candidates in oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel kinase inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study specific enzyme pathways and cellular processes.
• Contract Development & Manufacturing (CDMO): Supplied to CDMOs for scale-up synthesis under cGMP conditions for clinical trial material production.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Product Name	3-(2-Chloropyrimidin-4-Yl)-1H-Indole
CAS No.	945016-63-7
Molecular Formula	C12H8ClN3
Molecular Weight	229.66 g/mol
Synonyms	1H-Indole, 3-(2-chloro-4-pyrimidinyl)-; 3-(2-Chloro-4-pyrimidinyl)-1H-indole; 3-(2-Chloropyrimidin-4-yl)indole; 4-(1H-Indol-3-yl)-2-chloropyrimidine; 2-Chloro-4-(1H-indol-3-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 3-(2-Chloropyrimidin-4-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.