Description

tert-Butyl 6-Fluoro-3-Iodo-1H-indazole-1-carboxylate is a high-value, multi-functional chemical building block designed for advanced synthetic chemistry. This compound is engineered to provide a protected indazole scaffold, facilitating the efficient synthesis of complex molecules in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate fluorinated and iodinated heterocyclic motifs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its versatile reactive sites.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and pesticides with enhanced efficacy.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential intermediate for synthesizing specialty polymers and organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 6-Fluoro-3-Iodo-1H-Indazole-1-Carboxylate
CAS No.	944904-46-5
Molecular Formula	C₁₂H₁₂F I N₂O₂
Molecular Weight	362.14 g/mol
Synonyms	1H-Indazole-1-carboxylic acid, 6-fluoro-3-iodo-, 1,1-dimethylethyl ester; 6-Fluoro-3-iodo-1H-indazole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-fluoro-3-iodoindazole-1-carboxylate; 6-Fluoro-3-iodo-1-(tert-butoxycarbonyl)-1H-indazole; Boc-6-Fluoro-3-iodoindazole; 944904-46-5; tert-Butyl 6-fluoro-3-iodo-1H-indazole-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Fluoro-3-Iodo-1H-Indazole-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.