Description

4-Cyano-3-Iodo (1H)Indazole is a high-value, halogenated heterocyclic building block with the CAS number 944898-93-5. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a versatile intermediate for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific functional groups for structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of targeted kinase inhibitors and other small molecule drug candidates.
• Medicinal Chemistry Research: Used extensively in lead optimization and SAR exploration due to its reactive cyano and iodo functional groups.
• Agrochemical Development: Serves as a precursor for novel active ingredients in crop protection products.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and biological pathways.
• Material Science: Potential building block for organic electronic materials and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.

Basic Information

Product Name	4-Cyano-3-Iodo (1H)Indazole
CAS No.	944898-93-5
Molecular Formula	C8H4IN3
Molecular Weight	269.04 g/mol
Synonyms	3-Iodo-1H-indazole-4-carbonitrile; 4-Cyano-3-iodo-1H-indazole; 3-Iodo-4-cyanoindazole; 1H-Indazole-4-carbonitrile, 3-iodo-; 944898-93-5; 3-Iodo-1H-indazole-4-carbonitrile; 4-CN-3-I-1H-Indazole
EINECS	Contact for details

Quality Control

Our 4-Cyano-3-Iodo (1H)Indazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to reliable supply and batch-to-batch consistency supports your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.