Description

5‐Bromo‐6‐Fluoro‐2,3‐Dihydro‐1H‐Indol‐2‐One is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated indolinone core structure. This compound is of significant commercial interest for its role as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted small-molecule therapies.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization due to its versatile bromo and fluoro substituents.
• Organic Synthesis Building Block: Serves as a versatile scaffold for constructing more complex heterocyclic compounds through various cross-coupling and functionalization reactions.
• Agrochemical Research: Potential application in the development of new active ingredients for crop protection products.
• Material Science: Investigated as a monomer or precursor for specialty polymers and organic electronic materials.

Basic Information

Product Name	5‐Bromo‐6‐Fluoro‐2,3‐Dihydro‐1H‐Indol‐2‐One
CAS No.	944805-66-7
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	5-Bromo-6-fluoroindolin-2-one; 5-Bromo-6-fluoro-2,3-dihydro-1H-indol-2-one; 5-Bromo-6-fluorooxindole; 2H-Indol-2-one, 5-bromo-6-fluoro-1,3-dihydro-; 944805-66-7; 5-Br-6-F-oxindole
EINECS	Contact for details

Quality Control

Our 5‐Bromo‐6‐Fluoro‐2,3‐Dihydro‐1H‐Indol‐2‐One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.