Description

1H-Pyrrolo[2,3-B]Pyridin-5-Ylboronic Acid is a high-value boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel heterocyclic compounds, particularly in oncology and CNS drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in active pharmaceutical ingredient (API) development, especially for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic acid coupling partner for the synthesis of biaryl and heterobiaryl structures under mild conditions.
• Agrochemical Research: Used in the discovery and synthesis of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where specific heterocyclic architectures are required.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents to study biological pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and library production for client projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridin-5-Ylboronic Acid
CAS No.	944059-24-9
Molecular Formula	C7H7BN2O2
Molecular Weight	161.96 g/mol
Synonyms	5-Borono-1H-pyrrolo[2,3-b]pyridine; (1H-Pyrrolo[2,3-b]pyridin-5-yl)boronic acid; 1H-Pyrrolo[2,3-b]pyridine-5-boronic acid; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (pinacol ester precursor); 7-Azaindole-5-boronic acid; Azaindole boronic acid; 1H-Pyrrolo[2,3-b]pyridin-5-yl-B(OH)2
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridin-5-Ylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive cross-coupling applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially air/moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.