Description

Acebilustat is a potent and selective small-molecule inhibitor of leukotriene A4 hydrolase (LTA4H), a key enzyme in the inflammatory pathway. This compound is of significant interest for its potential to modulate inflammatory responses, offering a targeted approach for therapeutic development. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of novel treatments for chronic inflammatory and respiratory conditions.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for inflammatory diseases.
• Anti-inflammatory Drug Development: Investigated for its therapeutic potential in conditions such as chronic obstructive pulmonary disease (COPD), asthma, and cystic fibrosis.
• Biochemical Research: Used as a selective tool compound in enzymatic assays and studies to elucidate the LTA4H pathway and its role in inflammation.
• Formulation Development: Employed in the development of various dosage forms, including oral tablets and capsules, for clinical trial materials.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and the production of kilogram quantities under cGMP standards for advanced development phases.

Basic Information

Product Name	Acebilustat
CAS No.	943764-99-6
Molecular Formula	C₂₀H₂₀F₃N₃O₃
Molecular Weight	407.39 g/mol
Synonyms	CTX-4430; (S)-2-(4-(2-Cyclopropyl-1-(2-fluorobenzyl)-1H-benzo[d]imidazol-5-yl)butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; LTA4H Inhibitor; Leukotriene A4 Hydrolase Inhibitor; Acebilustatum
EINECS	Contact for details

Quality Control

Our Acebilustat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.