Description

8-Bromo-1,2-Dihydroisoquinolin-3(4H)-One is a versatile brominated isoquinolinone derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique halogenated heterocyclic structure makes it a valuable building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is primarily sought after by medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates targeting neurological disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used as a core scaffold or derivatization point for structure-activity relationship (SAR) studies and library synthesis.
• Agrochemical Development: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and as a substrate for further functionalization.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.
• Material Science Research: Potential monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	8-Bromo-1,2-Dihydroisoquinolin-3(4H)-One
CAS No.	943749-58-4
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	8-Bromo-1,2,3,4-tetrahydroisoquinolin-3-one; 8-Bromo-3,4-dihydro-1H-isoquinolin-3-one; 8-Bromo-1,2-dihydro-4H-isoquinoline-3-one; 8-Bromotetrahydroisoquinolin-3-one; 8-Bromo-3-oxo-1,2,3,4-tetrahydroisoquinoline; 8-Bromo-3-isoquinolinone; 943749-58-4; 8-Bromo-1,2,3,4-tetrahydro-3-isoquinolinone
EINECS	Contact for details

Quality Control

Our 8-Bromo-1,2-Dihydroisoquinolin-3(4H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.