Description

(5-Bromo-Thiophen-2-Yl)-Carbamic Acid tert-Butyl Ester CAS NO 943321-89-9 is a high-purity, protected heterocyclic amine derivative, specifically a Boc-protected 5-bromothiophene-2-amine. This compound serves as a critical pharmaceutical intermediate and organic building block for advanced synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules, particularly in medicinal chemistry programs targeting novel therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing functionalized thiophene cores.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to introduce the bromo-thiophene moiety into target molecules.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and pesticides.
• Material Science Precursor: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and advanced functional materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.
• Peptidomimetics and Bio-conjugation: The Boc-protected amine is a versatile handle for introducing the thiophene unit into peptides or for bioconjugation strategies.

Basic Information

Product Name	(5-Bromo-Thiophen-2-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	943321-89-9
Molecular Formula	C9H12BrNO2S
Molecular Weight	278.17 g/mol
Synonyms	tert-Butyl N-(5-bromothiophen-2-yl)carbamate; N-Boc-5-bromo-2-aminothiophene; 5-Bromo-2-((tert-butoxycarbonyl)amino)thiophene; Boc-5-Bromo-2-aminothiophene; N-(tert-Butoxycarbonyl)-5-bromothiophen-2-amine; 2-Amino-5-bromothiophene, N-Boc protected; tert-Butyl (5-bromo-2-thienyl)carbamate; 5-Bromothiophene-2-carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (5-Bromo-Thiophen-2-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. Our quality system is designed to support cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.