Description

5-Chloro-2-Methoxypyridine-3-Boronic Acid is a high-purity boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly in creating novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and inhibitors for studying enzyme function and protein-protein interactions.
• Ligand Synthesis for Catalysis: Used to prepare novel bidentate or tridentate ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	5-Chloro-2-Methoxypyridine-3-Boronic Acid
CAS No.	943153-22-8
Molecular Formula	C6H7BClNO3
Molecular Weight	187.39 g/mol
Synonyms	(5-Chloro-2-methoxypyridin-3-yl)boronic acid; 3-Borono-5-chloro-2-methoxypyridine; 5-Chloro-2-methoxy-3-pyridineboronic acid; 5-Chloro-2-methoxypyridine-3-boronic acid pinacol ester (common protected form); 3-Pyridineboronic acid, 5-chloro-2-methoxy-; Boronic acid, B-(5-chloro-2-methoxy-3-pyridinyl)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Methoxypyridine-3-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.