Description

1H-Pyrrolo[2,3-B]Pyridine-2-Carboxaldehyde, 1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional organic building block that combines a protected pyrrolopyridine aldehyde core with a versatile pinacol boronate ester group. This compound is specifically engineered for advanced cross-coupling reactions, enabling the efficient synthesis of complex heterocyclic scaffolds. It is an essential intermediate for research and development chemists in the pharmaceutical and agrochemical industries, particularly in the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety makes it an ideal partner for palladium-catalyzed coupling with aryl/heteroaryl halides to form biaryl linkages.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biological studies.
• Further Functionalization: The aldehyde group allows for subsequent transformations, including reductive amination, condensation, and oxidation.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-2-Carboxaldehyde, 1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	942920-60-7
Molecular Formula	C22H25BN2O5S
Molecular Weight	440.32 g/mol
Synonyms	1-(Phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxaldehyde; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde; 1-(Benzenesulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine-2-carboxaldehyde; 1H-Pyrrolo[2,3-b]pyridine-2-carboxaldehyde, 1-(phenylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 942920-60-7; BRN 14883470
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxaldehyde, 1-(Phenylsulfonyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect the boronate ester from moisture and the compound from potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.