Description

Methyl 5-Iodo-3-(2,2,2-Trifluoroacetamido)-Thiophene-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and manufacturers requiring precise molecular scaffolds to develop novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers focused on creating complex molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a versatile precursor for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the synthesis of advanced organic electronic materials, such as novel conjugated polymers and organic semiconductors, due to its thiophene core.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement, leveraging its iodine handle for further functionalization.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, bespoke organic molecules for clients.

Basic Information

Product Name	Methyl 5-Iodo-3-(2,2,2-Trifluoroacetamido)-Thiophene-2-Carboxylate
CAS No.	942589-44-8
Molecular Formula	C8H5F3INO3S
Molecular Weight	379.10 g/mol
Synonyms	Methyl 5-iodo-3-[(2,2,2-trifluoroacetyl)amino]thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-iodo-3-[(2,2,2-trifluoroacetyl)amino]-, methyl ester; 5-Iodo-3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylic acid methyl ester; Methyl 5-iodo-3-(trifluoroacetamido)thiophene-2-carboxylate; 942589-44-8; TFAT Ester; Iodo-trifluoroacetamido thiophene carboxylate methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Iodo-3-(2,2,2-Trifluoroacetamido)-Thiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.