Description

3-Bromo-5-Nitro-1-Trityl-1H-Indazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core functionalized with bromo and nitro groups and protected by a trityl moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted small molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological profile of indazole-based compounds.
• Chemical Biology: Serves as a versatile scaffold for developing chemical probes to study specific enzyme functions and cellular pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and organic synthesis methodologies.

Basic Information

Product Name	3-Bromo-5-Nitro-1-Trityl-1H-Indazole
CAS No.	942189-39-1
Molecular Formula	C26H18BrN3O2
Molecular Weight	484.35 g/mol
Synonyms	1H-Indazole, 3-bromo-5-nitro-1-(triphenylmethyl)-; 1-Trityl-3-bromo-5-nitro-1H-indazole; 3-Bromo-5-nitro-1-tritylindazole; 3-Bromo-5-nitro-1-(triphenylmethyl)-1H-indazole; 1-(Triphenylmethyl)-3-bromo-5-nitro-1H-indazole; 942189-39-1; 3-Bromo-5-nitro-1-trityl-1H-indazole
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Nitro-1-Trityl-1H-Indazole is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for advanced pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from prolonged exposure.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.