Description

tert-Butyl 3-(1-Amino-2-Methylpropan-2-Yl)-1H-Indole-1-Carboxylate is a protected indole derivative featuring both a Boc (tert-butoxycarbonyl) protecting group and a primary amine functional group. This compound is a crucial advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic organic chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within medicinal chemistry programs targeting complex heterocyclic structures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, especially those containing indole scaffolds.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Peptidomimetic Synthesis: The protected amine and carboxylic acid derivative make it suitable for constructing peptide-like molecules and enzyme inhibitors.
• Agrochemical Development: Acts as an intermediate in the research and production of advanced crop protection agents and pesticides.
• Organic Synthesis Reagent: Employed in multi-step synthetic routes to create complex natural products and specialty chemicals.
• Bioconjugation Chemistry: The reactive amine group allows for linking to other molecules, useful in probe and tracer development.

Basic Information

Product Name	tert-Butyl 3-(1-Amino-2-Methylpropan-2-Yl)-1H-Indole-1-Carboxylate
CAS No.	942148-12-1
Molecular Formula	C₁₇H₂₄N₂O₂
Molecular Weight	288.39 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 3-(1-amino-2-methyl-2-propanyl)-, 1,1-dimethylethyl ester; 3-(1-Amino-2-methylpropan-2-yl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(1-amino-2-methylpropyl)indole-1-carboxylate; 1-Boc-3-(1-amino-2-methylpropan-2-yl)indole; Boc-protected 3-(1-amino-2-methylpropan-2-yl)indole; 942148-12-1
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(1-Amino-2-Methylpropan-2-Yl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.