Description

Piroxicam-D3 CAS NO 942047-64-5 is a deuterium-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) Piroxicam, where three hydrogen atoms are replaced with the stable isotope deuterium. This compound is a critical internal standard used in quantitative analytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and bioanalytical studies. It is an essential tool for pharmaceutical researchers, clinical laboratories, and contract research organizations (CROs) engaged in drug development, metabolism studies, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of Piroxicam in biological matrices (e.g., plasma, serum, urine) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the parent drug and its metabolites, correcting for matrix effects and instrument variability.
• Bioanalytical Method Development and Validation: A key component in developing and validating robust, GLP-compliant analytical methods for regulatory submissions to agencies like the FDA and EMA.
• Clinical Research: Enables accurate measurement of Piroxicam concentrations in patient samples during clinical trials for pharmacokinetic profiling and bioequivalence studies.
• Forensic and Toxicological Analysis: Supports the accurate identification and quantification of Piroxicam in forensic toxicology cases.
• Pharmaceutical Quality Control: Can be utilized in advanced analytical techniques for impurity profiling and stability testing of Piroxicam drug substances and products.

Basic Information

Product Name	Piroxicam-D3
CAS No.	942047-64-5
Molecular Formula	C15H10D3N3O4S
Molecular Weight	334.37 g/mol
Synonyms	Piroxicam-d3; 4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide-d3; Deuterated Piroxicam; Piroxicam (phenyl-d3); [2H3]-Piroxicam; Piroxicam Internal Standard; Piroxicam-d3 (Major)
EINECS	Contact for details

Quality Control

Our Piroxicam-D3 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (≥95%), and chromatographic profile. Our quality system supports compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.