Description

3-Bromo-2-(4-Isocyanatophenyl)Thiophene is a high-value, multi-functional aromatic building block containing both a reactive isocyanate group and a brominated thiophene moiety. This unique bifunctional structure makes it a critical intermediate for synthesizing advanced materials and specialty chemicals. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the thiophene and isocyanate functionalities contribute to biological activity.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing high-performance polymers, polyurethanes, and specialty resins with tailored thermal and mechanical properties.
• Organic Semiconductor Research: Employed in the construction of π-conjugated systems for organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Ligand & Catalyst Development: Useful for creating novel ligands in coordination chemistry and catalysis, leveraging the bromine atom for further functionalization via cross-coupling reactions.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	3-Bromo-2-(4-Isocyanatophenyl)Thiophene
CAS No.	941716-97-8
Molecular Formula	C11H6BrNO2S
Molecular Weight	296.14 g/mol
Synonyms	3-Bromo-2-(4-isocyanatophenyl)thiophene; 4-(3-Bromothiophen-2-yl)phenyl isocyanate; 2-(4-Isocyanatophenyl)-3-bromothiophene; 3-Bromo-2-(p-isocyanatophenyl)thiophene; Thiophene, 3-bromo-2-[4-(isocyanato)phenyl]-; 941716-97-8; 3-Bromo-2-(4-isocyanato-phenyl)thiophene
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-2-(4-Isocyanatophenyl)Thiophene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), impurity profile, and moisture content. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.