Description

Pentafluorophenyl 5-Pyridin-3-Ylthiophene-2-Carboxylate is a high-value, multi-functional chemical building block featuring a pentafluorophenyl ester group and a pyridinyl-substituted thiophene core. This compound is specifically engineered for advanced organic synthesis, offering a reactive handle for coupling reactions and the introduction of fluorinated aromatic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting kinase inhibition or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the thiophene and pyridine heterocycles contribute to biological activity.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers and organic electronic materials, such as semiconductors for OLEDs or sensors.
• Chemical Biology: Employed as a probe or labeling reagent due to the reactive ester group, which can conjugate with amines under mild conditions.
• Organic Synthesis: A versatile reagent for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	Pentafluorophenyl 5-Pyridin-3-Ylthiophene-2-Carboxylate
CAS No.	941716-94-5
Molecular Formula	C₁₇H₆F₅NO₂S
Molecular Weight	383.29 g/mol
Synonyms	5-Pyridin-3-ylthiophene-2-carboxylic acid pentafluorophenyl ester; 3-(5-((Perfluorophenoxy)carbonyl)thiophen-2-yl)pyridine; Pentafluorophenyl 3-(thiophen-2-yl)pyridine-5-carboxylate; PFP 5-(3-Pyridyl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-(3-pyridinyl)-, 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Every batch of Pentafluorophenyl 5-Pyridin-3-Ylthiophene-2-Carboxylate is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure high purity and batch-to-batch consistency, critical for sensitive research and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.