Description

5-Bromo-4-Cyclohexylpyrimidine is a high-purity, halogenated pyrimidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized pyrimidine core with a bromine substituent for further cross-coupling reactions and a cyclohexyl group that can impart favorable steric and lipophilic properties to target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients, particularly for medicinal chemistry and crop protection applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the pyrimidine scaffold is a common bioactive motif.
• Material Science Precursor: Serves as a building block for creating specialized organic ligands, liquid crystals, or functional polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to create complex biaryl structures.
• Academic & R&D: A valuable reagent for universities and contract research organizations (CROs) exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-4-Cyclohexylpyrimidine
CAS No.	941294-28-6
Molecular Formula	C10H13BrN2
Molecular Weight	241.13 g/mol
Synonyms	4-Cyclohexyl-5-bromopyrimidine; 5-Bromo-4-cyclohexyl-pyrimidine; Pyrimidine, 5-bromo-4-cyclohexyl-; 941294-28-6; 5-Bromo-4-cyclohexyl pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Cyclohexylpyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.