Description

7-Chloro-4-Methyl-1H-Indole is a halogenated indole derivative serving as a versatile and high-value synthetic building block. This compound is critical for the development of novel pharmaceuticals and advanced organic materials due to its reactive indole core and strategically placed chloro and methyl substituents. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for use in medicinal chemistry, heterocyclic synthesis, and as a precursor for functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the biological activity of the indole scaffold.
• Material Science: Serves as a monomer or building block for creating advanced organic polymers, dyes, and photoactive materials.
• Medicinal Chemistry & SAR Studies: Employed extensively in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Chemical Synthesis: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and electrophilic substitution reactions to create complex, diversely functionalized molecules.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in exploratory organic synthesis and method development.

Basic Information

Product Name	7-Chloro-4-Methyl-1H-Indole
CAS No.	941294-27-5
Molecular Formula	C9H8ClN
Molecular Weight	165.62 g/mol
Synonyms	7-Chloro-4-methylindole; 4-Methyl-7-chloro-1H-indole; 1H-Indole, 7-chloro-4-methyl-; 7-Chloro-4-methyl-1H-indole; 4-Methyl-7-chloroindole; 7-Chloro-4-methylindole; 7-Chloro-4-methyl-1H-indole (CAS 941294-27-5)
EINECS	Contact for details

Quality Control

Our 7-Chloro-4-Methyl-1H-Indole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.