Description

1,3-Dichloro-7-Fluoroisoquinoline is a high-purity, multi-functional halogenated isoquinoline building block essential for advanced organic synthesis. Its unique molecular architecture, featuring strategically positioned chlorine and fluorine atoms, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides with enhanced activity and selectivity.
• Material Science Research: Serves as a building block for organic semiconductors, liquid crystals, and advanced polymers due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags, photoaffinity labels, and other molecular probes for biological target engagement studies.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and Negishi couplings to introduce the isoquinoline scaffold into complex molecules.
• Library Synthesis for Drug Discovery: A versatile scaffold for generating diverse compound libraries in high-throughput screening campaigns.

Basic Information

Item	Details
Product Name	1,3-Dichloro-7-Fluoroisoquinoline
CAS No.	941294-25-3
Molecular Formula	C9H4Cl2FN
Molecular Weight	216.04 g/mol
Synonyms	7-Fluoro-1,3-dichloroisoquinoline; 1,3-Dichloro-7-fluoro-isoquinoline; Isoquinoline, 1,3-dichloro-7-fluoro-; 941294-25-3; FC6H3(Cl)2N; Fluorodichloroisoquinoline
EINECS	Contact for details

Quality Control

Every batch of 1,3-Dichloro-7-Fluoroisoquinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, organic solvents, fluorides, and strong bases. Due to its light-sensitive nature and potential for oxidation, prolonged exposure to light and air should be minimized. For long-term storage, consider an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.