Description

Venlafaxine D6 is a deuterium-labeled analog of the widely prescribed serotonin-norepinephrine reuptake inhibitor (SNRI), Venlafaxine. This stable isotope-labeled compound is an essential tool for quantitative bioanalytical research, providing unmatched accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the precise quantification of Venlafaxine and its metabolites in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracing of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate highly sensitive and specific analytical methods compliant with FDA and ICH guidelines.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Facilitates reliable measurement of drug concentrations in patient samples to ensure therapeutic efficacy and safety.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques that require isotope-labeled standards for absolute quantification.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or related substances in drug substance batches.

Basic Information

Product Name	Venlafaxine D6
CAS No.	940297-06-3
Molecular Formula	C17H21D6NO2 *
Molecular Weight	283.42 g/mol (approx.)
Synonyms	(±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol D6; Venlafaxine-d6; DL-Venlafaxine D6; (R/S)-Venlafaxine D6; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol (hexadeuterated); Effexor D6 (labeled analog); WY-45,030 D6
EINECS	Contact for details

* Formula denotes hexadeuteration; exact position of deuterium atoms may vary.

Quality Control

Every batch of Venlafaxine D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive mass spectrometry applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting critical parameters including isotopic purity (D-enrichment), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment supports compliance with ISO 9001 standards and relevant ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.