Description

2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic acid pinacol ester group. This compound is a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures common in drug candidates.
• Pharmaceutical Intermediate: Serves as a versatile building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for fluorine-containing drugs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the difluoroaniline and boronate functionalities impart specific biological activity and stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and labeling strategies in the development of probes and tools for biological research.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis to create diverse compound libraries for screening against biological targets.

Basic Information

Product Name	2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine
CAS No.	939807-75-7
Molecular Formula	C12H16BF2NO2
Molecular Weight	255.07 g/mol
Synonyms	4-Amino-2,5-difluorophenylboronic acid pinacol ester; 2,5-Difluoro-4-aminophenylboronic acid pinacol ester; (4-Amino-2,5-difluorophenyl)boronic acid pinacol ester; 2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 939807-75-7; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-difluoroaniline
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay (by NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.