Description

3-(5-Nitro-1H-Benzimidazol-2-Yl)Benzoic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its benzimidazole core structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel benzimidazole-based drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic agents.
• API Synthesis: A crucial precursor in multi-step synthetic routes for active pharmaceutical ingredients, particularly those with nitro-substituted heterocycles.
• Biochemical Research: Employed in the development of enzyme inhibitors or receptor modulators due to the benzimidazole pharmacophore.
• Fine Chemical Production: Used in custom synthesis and contract manufacturing for specialized chemical entities.

Basic Information

Product Name	3-(5-Nitro-1H-Benzimidazol-2-Yl)Benzoic Acid Ethyl Ester
CAS No.	939409-10-6
Molecular Formula	C₁₆H₁₃N₃O₄
Molecular Weight	311.29 g/mol
Synonyms	Ethyl 3-(5-Nitro-1H-benzimidazol-2-yl)benzoate; 3-(5-Nitro-1H-benzo[d]imidazol-2-yl)benzoic acid ethyl ester; Benzoic acid, 3-(5-nitro-1H-benzimidazol-2-yl)-, ethyl ester; 939409-10-6; 5-Nitro-2-(3-(ethoxycarbonyl)phenyl)-1H-benzimidazole; Ethyl 3-(5-nitro-1H-1,3-benzodiazol-2-yl)benzoate
EINECS	Contact for details

Quality Control

Our 3-(5-Nitro-1H-Benzimidazol-2-Yl)Benzoic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.