Description

6-(1-(tert-Butoxycarbonyl)Piperidin-4-Yloxy)-1H-Indole-2-Carboxylic Acid CAS NO 937778-18-2 is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture that combines indole and piperidine motifs. This compound is of critical importance for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of targeted drug candidates, especially in oncology and CNS research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Used in the research and process development stages for new Active Pharmaceutical Ingredients (APIs), leveraging its functional groups for further derivatization.
• Bioconjugation & Probe Synthesis: The carboxylic acid moiety allows for coupling reactions, making it suitable for creating fluorescent probes or affinity labels for biochemical assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Product Name	6-(1-(tert-Butoxycarbonyl)Piperidin-4-Yloxy)-1H-Indole-2-Carboxylic Acid
CAS No.	937778-18-2
Molecular Formula	C19H24N2O5
Molecular Weight	360.41 g/mol
Synonyms	6-[1-[(tert-Butoxy)carbonyl]-4-piperidinyl]oxy]-1H-indole-2-carboxylic acid; 6-(1-Boc-piperidin-4-yloxy)-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 6-[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]oxy]-; 6-(1-Boc-4-piperidyloxy)indole-2-carboxylic acid; Boc-Pip-O-Indole-2-COOH; 937778-18-2; tert-Butyl 4-((2-carboxy-1H-indol-6-yl)oxy)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 6-(1-(tert-Butoxycarbonyl)Piperidin-4-Yloxy)-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.