Description

5-Bromoisoquinoline-8-Sulfonyl Chloride is a high-purity, multi-functional chemical building block of significant importance in advanced organic synthesis. Its core value lies in its dual functionality, serving as a versatile sulfonylation reagent and a halogenated heterocyclic precursor, enabling the construction of complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the development of new drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting enzymes and receptors where the isoquinoline scaffold is relevant.
• Sulfonamide Synthesis: Acts as a crucial reagent for introducing the sulfonyl chloride group, facilitating the creation of diverse sulfonamide libraries for biological screening.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that utilize halogenated heterocycles for enhanced activity.
• Material Science Precursor: Employed in the synthesis of specialized organic ligands and functional molecules for advanced materials, such as metal-organic frameworks (MOFs) or organic semiconductors.
• Chemical Biology Probes: Useful for creating activity-based probes or affinity labels to study protein function and enzyme mechanisms in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds on a commercial scale.

Basic Information

Product Name	5-Bromoisoquinoline-8-Sulfonyl Chloride
CAS No.	937632-19-4
Molecular Formula	C9H5BrClNO2S
Molecular Weight	306.56 g/mol
Synonyms	8-Isoquinolinesulfonyl chloride, 5-bromo-; 5-Bromo-8-isoquinolinesulfonyl chloride; 5-Bromoisoquinoline-8-sulfonyl chloride; 5-Bromo-isoquinoline-8-sulfonyl chloride; 937632-19-4; AI3-32862; BRN 12508643; SCHEMBL218248; ZINC000103049757; AKOS040759230
EINECS	Contact for details

Quality Control

Our 5-Bromoisoquinoline-8-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.